|
KMID : 1134820080370060696
|
|
Journal of the Korean Society of Food Science and Nutrition
2008 Volume.37 No. 6 p.696 ~ p.700
|
|
|
Genotoxicological Safety of Octadeca-9,12-dienyl-3,4,5-trihydroxybenzoate from Gallic and Linoleic Acids and Its Biological Functions in Cream-based Emulsion
|
|
Jung Samooel
Song Hyun-Pa
Lee Na-Young
Jang Ae-Ra
Jo Cheo-Run
|
|
|
Abstract
|
|
|
|
The objective of this study was to investigate the genotoxicological safety and biological functions of octadeca-9,12-dienyl-3,4,5-trihydroxybenzoate (GA-LA) in cream-based emulsion for future application as a functional cosmetic material as well as food. GA-LA was synthesized chemically from gallic acid and linoleic acid. The Ames test showed that GA-LA did not have mutagenical toxicity. The control cream-based emulsion containing GA-LA was prepared by commercial method and tested for 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity. Ferric reducing antioxidant power (FRAP) and inhibition effect against tyrosinase of the emulsions were tested for the evaluation of antioxidative and skin-whitening activities. The results showed that DPPH radical scavenging activity in the cream-based emulsion containing GA-LA was higher (52.65%) than that of the control (4.30%). The FRAP value of the sample was 12.85%, however, no activity was found in control. The inhibition effect of tyrosinase showed also a higher value (26.29%) when compared to the control. The results indicate that GA-LA, which showed superior antioxidative and skin-whitening activities in cream-based emulsion, is a useful functional material applicable in cosmetic products as well as food.
|
|
|
KEYWORD
|
|
|
octadeca-9, 12-dienyl-3, 4, 5-trihydroxybenzoate, antioxidative, skin-whitening, genotoxicological safety
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|